The chronomodulated drug delivery system is widely used for treatment of diseases occurs due to circadian changes in the body the body. This system is aims to release drugs at a programmed pattern i.e. at appropriate time and/or atappropriate site of action. It provide the scope for controlled release dosage form formulation which has significant therapeutic importance. It release the drug at desire time as per physiological need of disease and it also improved the therapeutic efficacy and patient compliance. Ideally such systems aim to match drugrelease rate to a biological requirement of a given diseasetherapy and thus to manage the disease while minimizing treatment�s side effects. In this review the techniques used for formulation of this system are given.
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